DDueted

A spreadsheet, a CRM, a sending tool. Where each one stops.

Each of them does part of this job properly. The question worth answering is which part, and what you end up doing by hand for the rest.

Capability comparison

Partial means it can be forced with manual work or a paid add-on, not that it works when you open the box. Spreadsheet and generic CRM describe the category, not one named product.

Said plainly, including where this one is not the answer.

A spreadsheet
Genuinely good at being a list, and that is the whole problem: a list cannot send, cannot receive, and holds no state between you looking at it. Every part of the job that involves a message leaving or arriving happens somewhere else, which means the spreadsheet is out of date from the moment you close it.
A generic CRM
Powerful and well built, for selling a product to a company. Nothing in it knows what a domain is, so there is no exact match to reason about, no walk-away floor, no renewal date, and no for-sale page. You can model those as custom fields, and then you own a schema you have to maintain.
A cold email tool
This is the closer comparison, and the honest one: Instantly, Smartlead and Lemlist send sequences from rotating warmed mailboxes, and they do it well. They start from a list you bring. Nothing in them can tell you which companies should be on that list for the domain you are holding, because they have never heard of the domain.
Dueted
The part upstream of sending is the product: the domain is the root, the companies whose exact match it is are found and scored under it, and the audience is a rule over that rather than a file. Then it sends on warmed mailboxes and brings the reply back. If you only need the sending half, the tools above are mature and you should use one.

If the list is the hard part, start here.

Bring the domains. The research finds who should hear about them, and the rule keeps the audience current without another import.

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